The cees dekker Diaries
The cees dekker Diaries
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests involve:
1996, very first mesoscopic cost density waves equipment; and very first electrical measurements on one metallic nanocluster among nanoelectrodes
‘It was only a make a difference of choosing up a e-book on cell biology and starting to read. I'd originate from a environment of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Doing work at space temperature with molecular biology kits.
Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
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Microbiology has only existed for a century, given that we started to examine micro-organisms additional very seriously. I assumed nanobiology was an appropriate term, simply because all molecular biological appropriate interactions happen with the nanoscale: a protein is some nanometres in sizing, DNA is two nm thick.’
All parameters ended up the same for each panel In this particular online video, aside from the initial placement from the 6hb rod (proven in blue) to the nanopore. Simulations that terminated early due to translocation from the rod in the pore are marked by a gray background.
2011, initial in vitro measurements of transport throughout only one biomimetic nuclear pore elaborate; progress of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
2003, demonstrated the very first biosensors made outside of a carbon nanotube; solved the framework and mechanism of DNA repair proteins; and discovery of a new system for fabricating stable-condition nanopores for DNA translocation
Really neat, but that wasn’t genuinely where by my curiosity lay. I planned to pioneer And that i had the feeling which was no longer attainable, since the most interesting basic insights experienced now been uncovered. But my area experienced developed several remarkable new tools to measure specific molecules. I made a decision which i desired to use this to biology, to have a look at it from a Bodily viewpoint.’
‘The idea that There exists this kind of thing like a starting, a giant bang, is now an interesting signpost to contemplate that there was a creator. But far more commonly, and on The premise of pure rationality, I also get there in a Christian interpretation of truth. An atheistic worldview is a naturalistic worldview: fundamentally, you will find only atoms and organic forces that we will measure.
2006, initial demonstration of molecular sorting in the lab with a chip using biomotors; discovery of nanobubbles in sound-condition nanopores; and to start with estimate of electrokinetic energy conversion within a nanofluidic channel
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental examine of ions conduction in nanofluidic channels; initial electrochemistry with unique solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; 1st electrical docking of microtubules on kinesin-coated nanostructures; ceesdekker.net initial biophysics characterization with the mechanical Homes of double-stranded RNA; and first solitary-molecule study of DNA translocation by a restriction-modification enzyme.